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Gulf War BBB changes with DEET, PB, and permethrin
Gulf War BBB changes with DEET, PB, and permethrin
------------------------------------------------------------ J Toxicol Environ Health A. 2004 Jan;67(2):163-92. Stress and combined exposure to low doses of pyridostigmine bromide, deet, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum. Abdel-Rahman A, Abou-Donia S, El-Masry E, Shetty A, Abou-Donia M. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA. Exposure to a combination of stress and low doses of the chemicals pyridostigmine bromide (PB), DEET, and permethrin in adult rats, a model of Gulf War exposure, produces blood-brain barrier (BBB) disruption and neuronal cell death in the cingulate cortex, dentate gyrus, thalamus, and hypothalamus. In this study, neuropathological alterations in other areas of the brain where no apparent BBB disruption was observed was studied following such exposure. Animals exposed to both stress and chemical exhibited decreased brain acetylcholinesterase (AChE) activity in the midbrain, brainstem, and cerebellum and decreased m2 muscarinic acetylcholine (ACh) receptor ligand binding in the midbrain and cerebellum. These alterations were associated with significant neuronal cell death, reduced microtubule-associated protein (MAP-2) expression, and increased glial fibrillary acidic protein (GFAP) expression in the cerebral cortex and the hippocampal subfields CA1 and CA3. In the cerebellum, the neurochemical alterations were associated with Purkinje cell loss and increased GFAP immunoreactivity in the white matter. However, animals subjected to either stress or chemicals alone did not show any of these changes in comparison to vehicle-treated controls. Collectively, these results suggest that prolonged exposure to a combination of stress and the chemicals PB, DEET, and permethrin can produce significant damage to the cerebral cortex, hippocampus, and cerebellum, even in the absence of apparent BBB damage. As these areas of the brain are respectively important for the maintenance of motor and sensory functions, learning and memory, and gait and coordination of movements, such alterations could lead to many physiological, pharmacological, and behavioral abnormalities, particularly motor deficits and learning and memory dysfunction. PMID: 14675905 [PubMed ~ in process]
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#2
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They are 'fishing' - They don't really know
I have looked into some of these things; but when you look up what they are supposed to do, they don't do all the things that are the "gulf war syndrome' symptoms.
I started a comparison here Since there are known exposure to 2-butoxyethanol and diethylene glycol monobutyl ether Why not check these? Can anyone locate the known sources of exposure to troops? I read that the Navy Seabees had a high rate of Gulf War Syndrome Symptoms. Why is that, I wonder? Why do people not exactly serving in the gulf have them, too? At least the Gulf War Vets have been highly studied; but what will we say when today's troops come down with the same? More background & one possible source of chemical harm
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Look into BUTYL for CFIDS, CFS, FM & 'Military Syndromes' * An e-mail request to the CDC on Flu Symptoms Traces of blood in urine? * Diarrhea then Constipation? Seizures Fainting Dizziness * |
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