USS PT-108, an 80-foot ELCO type motor torpedo boat, was placed in service with Motor Torpedo Boat Squadron FIVE in early July 1942. This squadron operated in the Panama Canal Zone area beginning in September 1942 and was transported across the Pacific to the Solomon Islands in the spring of 1943. It moved forward to Rendova, in the Central Solomons, in July 1943. During the next two months PT-108 took part in a number of engagements with the enemy. She was present during the 1-2 August night action in the Blackett Strait that resulted in the loss of her sister boat PT-109. The following night, while patrolling off Vella Lavella, PT-108 and her companions were repeatedly attacked by Japanese aircraft, but she was not damaged. However, on 22 August she participated in a daylight raid against the coast of Kolombangara and was repeatedly struck by enemy fire, suffering serious casualties among her crew.

PT-108 remained with MTB 'Ron FIVE during the rest of the Central Solomons and Admiralties campaign. Transferred to the Southwest Pacific area late in 1944, she was reassigned to Motor Torpedo Boat Squadron TEN in mid-February 1945. Service in and around the Philippines followed, continuing through the end of World War II. With the other surviving boats of the squadron, PT-108 was placed out of service and destroyed in November 1945.