USS Tuscumbia, a 575-ton casemate ironclad river gunboat built at Cincinnati, Ohio, was commissioned in March 1863. She was immediately in action, taking part in the recapture of Fort Heiman on 12-14 March. On 1 April, she led a reconnaissance up the Yazoo River. Tuscumbia next participated in the Mississippi Squadron's night-time run past Vicksburg on 16-17 April, during which she towed the damaged transport Forest Queen out of danger. On 29 April, she took part in the attack on Grand Gulf, and was disabled after receiving 81 hits from Confederate artillery. In May, after repairs, Tuscumbia bombarded the Vicksburg batteries. For most of the rest of the Civil War, she was under repair or laid up, being formally decommissioned in February 1865. USS Tuscumbia was sold in November 1865 and abandoned by her owners in 1867.