Cochise (A-da-tli-chi = "hardwood", also Cheis) (c. 1812?June 9, 1874) was a chief (nantan) of the Chokonen ("central" or "real" Chiricahua) band of the Chiricahua Apache and the leader of an uprising that began in 1861. Cochise was the most famous Apache leader to resist intrusions by whites during the 19th century. He was described as a large man, for the time, with a muscular frame and classical Roman features and long black hair he wore in traditional Apache style.

Cochise and the Chokonen-Chiricahua lived in the area that is now the northern Mexican region of Sonora, New Mexico and Arizona, which were traditional Apache territories until the coming of the Europeans. Due to encroachment by Spain and later Mexico, the Chokonen and Nednhi-Chiricahua became increasingly dependant upon food rations issued by the Mexican government to placate them. When this practice was abruptly ended in 1831, the various Chiricahua bands resumed raids to acquire food. The Mexican government began a series of military operations in order to either capture or neutralize the Chiricahua, but met with stiff resistance from Cochise and the Apache who were implacable foes. Mexican troops were largely unsuccessful in their attempts and were often fought to a stand-still by the Apache and Cochise. As part of their attempts at controlling the Chiricahua, Mexican forces, often with the help of American and Native American mercenaries, began to kill Apache civilians including Cochise's father and this hardened Cochise's resolve and gave the Chiricahua more reason for vengeance. Mexican forces were finally able to capture Cochise in 1848 during an Apache raid on Fronteras, Sonora, but gave him up as part of an exchange for nearly a dozen Mexican hostages.

The region inhabited by the Apache had experienced increased tension between the Apache and European (including early Spanish encroachment) settlers from about 1831 until the greater part of the area was annexed by the United States in 1850, which ushered in a brief period of relative peace. Cochise worked as a woodcutter at the stagecoach station in Apache Pass for the Butterfield Overland line.

The tenuous peace did not last as American encroachment into Apache territory continued. The formal peace ended in 1861 when an Apache raiding party drove away a local rancher's cattle and kidnapped his 12-year-old son. Cochise and five others of his band were falsely accused of the incident (which had actually been done by the Coyotero band of Apaches), and were ordered by an inexperienced Army officer (Lt. George Bascom) to report to the fort for questioning. When they went there and maintained their innocence the group was arrested and imprisoned.

The five soon mounted an escape attempt; one was killed and Cochise was shot three times but managed to slip away. He quickly took hostages to use in negotiations to free the other four Chiricahua. However, the plan backfired and both sides killed all their hostages in what was later known as "The Bascom Affair." Bascom's retaliation included hanging Cochise's brother and two of his nephews, which served to further enrage Cochise.

Cochise then joined with his father-in-law Mangas Coloradas (engl: "Red Sleeves", Kan-da-zis Tlishishen), the Bedonkohe-Chiricahua Apache chief, in a long series of retaliatory skirmishes and raids among the settlements. Many were killed on both sides, but the Apache began to achieve the upper hand, which prompted the United States Army to send an expedition (led by General James Carleton).

At Apache Pass in 1862, Cochise and Mangas Coloradas, with 500 fighters, held their ground against a force of 3000 California volunteers under Carleton until howitzer artillery fire was brought to bear on their position. The impasse continued until both parties agreed to parley. During what was to be a peaceful parley session the Americans took the unsuspecting Mangas Coloradas prisoner and then later executed him. This continued a series of incidents that fanned the flames of enmity between the encroaching Americans and the Apache. For Cochise, the Americans held nothing sacred and had violated the rules of war by capturing Mangas Coloradas during a parley session. Cochise and the Apache continued their raids against American and Mexican settlements and military positions throughout the 1860s.

Following various skirmishes, Cochise and his men were gradually driven into the Dragoon Mountains but were nevertheless able to use the mountains as cover and as a base to continue significant skirmishes against white settlements from. This was the situation until 1871 when General George Crook assumed command and used other Apaches as scouts and informants and was thereby able to force Cochise's men to surrender. Cochise was taken into custody in September of that year.

The next year the Chiricahua were ordered to Tularosa Reservation in New Mexico but refused to leave their ancestral lands in Arizona, which were guaranteed to them under treaty. Cochise managed to escape again and renewed raids and skirmishes against settlements through most of 1872. A new treaty was later negotiated by General Oliver O. Howard as the Americans relented to some of the Apaches' terms and Cochise quietly retired to an Arizona reservation where he died of natural causes.