USS Broome, a 1190-ton Clemson class destroyer built at Philadelphia, Pennsylvania, was commissioned at the end of October 1919. After brief service along the U.S. East Coast, in May 1920 she steamed across the Atlantic to begin several months in European waters between the Baltic Sea and the Mediterranean. Later in the year she voyaged to the Far East for a tour with the Asiatic Fleet. Broome returned to the United States in 1922 and was decommissioned at San Diego, California, in December of that year.

Broome recommissioned in February 1930 and spent nearly all of the decade operating in the Pacific. She was transferred to the Atlantic in May 1939 and, after the outbreak of war in Europe in September, participated in Neutrality Patrols. As relations with Germany deteriorated during 1941, she took part in convoy operations between the U.S. and Iceland.

Once the United States formally entered World War II in December 1941, Broome continued her Atlantic area convoy and patrol service. Among other missions, she escorted several convoys across the ocean to North Africa and the British Isles. The destroyer also was employed on training duties, and in 1945 this became her primary purpose. In May of that year she was disarmed, redesignated AG-98 and subsequently assigned to the the Atlantic Fleet's Operational Training Command at Guantanamo Bay, Cuba. Broome went to the Philadelphia Navy Yard in December 1945 to begin inactivation preparations. Decommissioned in May 1946, she was sold for scrapping in November 1946.

USS Broome was named in honor of Lieutenant Colonel John Lloyd Broome, USMC, (1824-1898), who served in the U.S. Marine Corps from 1848 until 1888.